Formulation

• HA Concentration: 24 mg/mL
• Lidocaine: 0.3% for enhanced comfort

Product Variants & Indications

1. NEURAMIS™

   • Particle Size: Small
   • Injection Depth: Superficial dermis
   • Use: Very fine lines—periorbital, perioral, worry lines

2. NEURAMIS™ Deep

   • Particle Size: Medium
   • Injection Depth: Mid-dermis
   • Use: Moderate wrinkles—glabellar folds, nasolabial lines, lip contouring

3. NEURAMIS™ Volume

   • Particle Size: Large
   • Injection Depth: Deep dermis or superficial subcutis
   • Use: Deep folds—marionette and nasolabial lines; lip plumping; cheek & chin enhancement

Areas of Treatment

• Marionette lines
• Nasolabial folds
• Forehead wrinkles
• All facial wrinkles
• Lip contouring & plumping
• Chin and cheek augmentation

Administration & Protocol

• Needle: 27 G × ½″ (13 mm) ultra-thin wall or 30 G fine needle
• Injection Depth: Variant-specific (superficial to deep dermis)
• Technique: Linear threading or small bolus
• Interval: Every 3–6 months, tailored to patient needs

Expected Results

• Onset: Immediate hydration and volume restoration
• Duration: 6–12 months, depending on product and patient factors
• Effect: Smoother skin texture, reduced wrinkle appearance and enhanced facial contours

Storage & Handling

• Temperature: Store at 2–25 °C; avoid freezing, heat and direct sunlight
• Shelf Life: 24 months from manufacture
• Packaging: 1 mL prefilled syringe

Safety Profile

NEURAMIS™ is biocompatible and fully biodegradable. Lidocaine minimizes injection discomfort. Common, transient side effects include swelling, bruising or redness. Serious complications are rare but underscore the need for administration by qualified professionals.