Indication: Moderate to Severe Glabellar Lines

Dysport targets frown lines between the eyebrows by temporarily reducing muscle activity. When injected into the corrugator and procerus muscles, it softens existing lines and prevents new ones from forming, restoring a smoother, more relaxed appearance.

Mechanism of Action

Intramuscular injection of Dysport blocks acetylcholine release at the neuromuscular junction, producing a localized, reversible muscle relaxation. This precise approach confines its effect to treated areas without impacting surrounding muscles.

Clinical Profile

• Onset of action: 2–5 days post-injection
• Peak effect: Approximately 2 weeks
• Duration: 3–4 months (variable by treatment area and patient)

Dosage & Reconstitution

Reconstitute with preservative-free 0.9% sodium chloride:

• 1 mL saline yields 50 U per 0.1 mL
• 2.5 mL saline yields 20 U per 0.1 mL
• 5 mL saline yields 10 U per 0.1 mL
  Use the reconstituted solution within 24 hours. Administer per approved dosing guidelines for each indication.

Aesthetic Applications

• Glabellar lines
• Forehead lines
• Crow’s feet

Therapeutic Applications

• Cervical dystonia
• Upper and lower limb spasticity
• Chronic migraine prevention
• Axillary hyperhidrosis
• Blepharospasm

Chemical & Physical Properties

• Formula: C₆₇₆₀H₁₀₄₄₇N₁₇₄₃O₂₀₁₀S₃₂
• Molar mass: ≈ 149,320 g/mol
• Log P: –0.368 (low lipid solubility)
• Stability: Stable at 14.86 °C / 0.1011 MPa for therapeutic use

Storage

Store lyophilized vials at 2–8 °C; do not freeze. After reconstitution, keep between 2–8 °C and use within 24 hours.

Safety & Precautions

Common adverse events include injection-site pain, swelling, bruising, headache, flu-like symptoms, and temporary eyelid or eyebrow ptosis. Serious complications (rare) may involve dysphagia, breathing difficulties, or speech impairment, especially at higher doses. Always administer under qualified supervision.