DYSPORT 500U
DYSPORT is a highly purified formulation of Botulinum Toxin Type A, a neurotoxin produced by Clostridium botulinum. Each vial contains 500 units (U) of active toxin and is indicated for both medical and aesthetic use.
Indication: Moderate to Severe Glabellar Lines
Dysport targets frown lines between the eyebrows by temporarily reducing muscle activity. When injected into the corrugator and procerus muscles, it softens existing lines and prevents new ones from forming, restoring a smoother, more relaxed appearance.
Mechanism of Action
Intramuscular injection of Dysport blocks acetylcholine release at the neuromuscular junction, producing a localized, reversible muscle relaxation. This precise approach confines its effect to treated areas without impacting surrounding muscles.
Clinical Profile
- Onset of action: 2–5 days post-injection
- Peak effect: Approximately 2 weeks
- Duration: 3–4 months (variable by treatment area and patient)
Dosage & Reconstitution
Reconstitute with preservative-free 0.9% sodium chloride:
- 1 mL saline yields 50 U per 0.1 mL
- 2.5 mL saline yields 20 U per 0.1 mL
- 5 mL saline yields 10 U per 0.1 mL
Use the reconstituted solution within 24 hours. Administer per approved dosing guidelines for each indication.
Aesthetic Applications
- Glabellar lines
- Forehead lines
- Crow’s feet
Therapeutic Applications
- Cervical dystonia
- Upper and lower limb spasticity
- Chronic migraine prevention
- Axillary hyperhidrosis
- Blepharospasm
Chemical & Physical Properties
- Formula: C₆₇₆₀H₁₀₄₄₇N₁₇₄₃O₂₀₁₀S₃₂
- Molar mass: ≈ 149,320 g/mol
- Log P: –0.368 (low lipid solubility)
- Stability: Stable at 14.86 °C / 0.1011 MPa for therapeutic use
Storage
Store lyophilized vials at 2–8 °C; do not freeze. After reconstitution, keep between 2–8 °C and use within 24 hours.
Safety & Precautions
Common adverse events include injection-site pain, swelling, bruising, headache, flu-like symptoms, and temporary eyelid or eyebrow ptosis. Serious complications (rare) may involve dysphagia, breathing difficulties, or speech impairment, especially at higher doses. Always administer under qualified supervision.
